Louis pasteur biography completado

In The Private Science of Louis Pasteur, Gerald Geison has written a controversial biography that finally penetrates the secrecy that has surrounded much of.
Louis Pasteur Linda Wasmer Smith,2007-07-01 Presents a biography of the noted French scientist whose discoveries, including a rabies vaccine and.
The Private Science of Louis Pasteur Gerald L. Geison,2014-07-14 In The Private Science of Louis Pasteur, Gerald Geison.

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Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

Background

Conventional anti-infectious vaccines are primarily intended to target specific pathogens by enhancing an antigen-specific adaptive immune response. This response is based on triggering B and T lymphocytes that, by virtue of their clonally segregated antigen receptors, generate effector, and memory cells. Proliferation and differentiation of specific lymphocytes is the basis of immunological memory, a hallmark of the adaptive immune response and the rationale behind conventional vaccines. Louis Pasteur built on the work of Edward Jenner to develop the principles of using attenuated live microbes to prevent the pathogen's caused disease (1). Pre-exposure vaccination was a major breakthrough in the prevention of many infectious diseases. His rabies vaccine for post-exposure prophylaxis in the severely ill boy Joseph Meister in 1885 raised the concept of therapeutic vaccines (2).

Immunological adaptive memory has been traditionally defined as long-t

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The Private Science of Louis Pasteur /

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The Private Science of Louis Pasteur /

Summary:In The Private Science of Louis Pasteur, Gerald Geison has written a controversial biography that finally penetrates the secrecy that has surrounded much of this legendary scientist's laboratory work. Geison uses Pasteur's laboratory notebooks, made available only recently, and his published papers to present a rich and full account of some of the most famous episodes in the history of science and their darker sides--for example, Pasteur's rush to develop the rabies vaccine and the human risks his haste entailed. The discrepancies between the public record and the "private science" of Louis Pasteur tell us as much about the man as they do about the highly competitive and political world he learned to master. Although experimental ingenuity served Pasteur well, he also owed much of his success to the polemical virtuosity and political savvy that won him unprecedented financial support from the French state during the late nineteenth century. But a close look at his greatest achievements raises ethical issue